Muscle dysfunction in COPD.
نویسندگان
چکیده
Esther Barreiro and Gary Sieck Respiratory Medicine Department—Lung Cancer Research Group, Institute of Medical Research of Hospital del Mar (IMIM)-Hospital del Mar, Parc de Salut Mar, Barcelona Biomedical Research Park (PRBB), Barcelona, Spain; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Bunyola, Majorca, Balearic Islands, Spain; and Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota
منابع مشابه
Structural and functional changes of peripheral muscles in chronic obstructive pulmonary disease patients.
PURPOSE OF REVIEW The purpose of this review is to identify new advances in our understanding of skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease (COPD). RECENT FINDINGS Recent studies have confirmed the relevance of muscle dysfunction as an independent prognosis factor in COPD. Animal studies have shed light on the molecular mechanisms governing skeletal mus...
متن کاملEpigenetic regulation of muscle phenotype and adaptation: a potential role in COPD muscle dysfunction.
Quadriceps muscle dysfunction occurs in one-third of patients with chronic obstructive pulmonary disease (COPD) in very early stages of their condition, even prior to the development of airway obstruction. Among several factors, deconditioning and muscle mass loss are the most relevant contributing factors leading to this dysfunction. Moreover, epigenetics, defined as the process whereby gene e...
متن کاملHIGHLIGHTED TOPIC Muscle Dysfunction in COPD Pathophysiology of muscle dysfunction in COPD
Gea J, Agustí A, Roca J. Pathophysiology of muscle dysfunction in COPD. J Appl Physiol 114: 1222–1234, 2013. First published March 21, 2013; doi:10.1152/japplphysiol.00981.2012.—Muscle dysfunction often occurs in patients with chronic obstructive pulmonary disease (COPD) and may involve both respiratory and locomotor (peripheral) muscles. The loss of strength and/or endurance in the former can ...
متن کاملفراوانی نارسایی بطن چپ در بیماران مبتلا به بیماری انسدادی مزمن ریوی: گزارش کوتاه
Background: Chronic obstructive pulmonary disease (COPD) and heart failure are prevalent comorbidities affecting a vast proportion of the world population, responsible for significant morbidity and mortality, their coexistence is more frequent than previously recognized that poses important diagnostic and therapeutic challenges. We intend to determine the prevalence of concomitant left ventricu...
متن کاملHIGHLIGHTED TOPIC Muscle Dysfunction in COPD Role of autophagy in COPD skeletal muscle dysfunction
Hussain SN, Sandri M. Role of autophagy in COPD skeletal muscle dysfunction. J Appl Physiol 114: 1273–1281, 2013. First published October 18, 2012; doi:10.1152/japplphysiol.00893.2012.—Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by parenchymal damage and irreversible airflow limitation. In addition to lung dysfunction, patients with COPD develop weight loss, ma...
متن کاملبررسی عملکرد بطن راست در بیماران مبتلا به COPD با یا بدون پولموناری هایپرتانسیون براساس معیارهای اکوکاردیوگرافیک و مقایسه آن با افراد سالم
Background and Aim: Pulmonary hypertension is an independent risk factor in COPD. Echocardiographic evaluation is important for determination of prognosis in these patients. Cardiovascular manifestations in COPD include increased arterial stiffness, ischemic heart disease, chronic heart failure and cor-pulmonale. Some studies suggest that right ventricular (RV) dysfunction occurs in early sta...
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ورودعنوان ژورنال:
- Journal of applied physiology
دوره 114 9 شماره
صفحات -
تاریخ انتشار 2013